TMU researchers managed to develop an accurate method to measure tiny amounts of medicine in biological samples with the use of a kind of Nano-absorbent.
Concerning this new method, Dr. Yadollah Yamini, faculty member of the university said: “We proposed a method to extract solid phase from inside a tube filled by Nano-absorbent through applying voltage in order to analyze acidic medicines in biological samples such as urine and plasma.”
He reminded: “this method makes it possible to connect the micro-extraction of a controlled phase with a potential and on-line flow to a liquid chromatography system.”
Yamini emphasized: “After completing the steps of designing and optimizing the method, its use to measure Mefenamic Acid and Diclofenac in real samples of plasma and urine was examined and the results showed that the proposed method in this research can measure ionic medicines in biological samples with high accuracy and precision”.
A faculty member of the university attributed the innovation of this method to the application of Nano-absorbent-filled tubes along with voltage and added that, the use of Nano-absorbent filled tubes increases the amount of Nano-absorbent for extraction and boosts extraction efficiency.
Dr. Yamini also added: “moreover, since this method is on-line, it has a higher analytical precision and decreases hand involvement in extraction, an issue which leads to more accurate results”.
He described Nano-absorbent used in these studies as Poly-Pyrrole Nano-particles, and added: “Due to the high surface area of these Nano-particles, they increase extraction efficiency in medicines.”
In fact, the new method shortens medicine extraction time significantly.
It should be noted here that the research was carried out by Hamid Ashabi; a PhD alumni, Dr. Yadollah Yamini and Dr. Maryam Shamsaie, faculty members of the Basic Sciences School, the results of which have been published in Talanta Magazine with the impact factor of 4.162.